By Sudhir Agrawal
Prime researchers provide an authoritative survey and research of the most recent findings at the quick improvement of antisense oligonucleotides healing and their program in a variety of in vivo version platforms. The book's high-profile individuals supply well timed money owed in their cutting-edge ideas, discussing such subject matters because the synthesis and purification of oligonucleotides, their choice for a selected gene goal, various tools of management, and using quite a few mobilephone strains and cellphone tradition platforms. additionally they learn questions of mobile uptake, in vitro organic job, in vivo organic job, the pharmacology and pharmacokinetics of oligonucleotides, and the applying of oligonucleotides to the significant apprehensive process.
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Extra info for Antisense Therapeutics
1990) Inducible cell adhesion molecule 110 (INCAM10) IS an endothelial receptor for lymphocytes J Exp Med 171, 1369-1374 55. , and Lobb, R (1989) Direct expression clonmg of vascular cell adhesion molecule 1, a cytokme-Induced endothelial protein that binds to lymphocytes. Cell 59, 1203-1211 56 Bevilacqua, M. , Pober, J. , Mendrick, D. L , Cotran, R. , Zounes, M. A, Freier, S M , Lima, W F , and Bennett, C. F. (1991) Antisense ohgonucleottdes inhibit intercellular adhesion molecule 1 expression by two distmct mechamsms J Bzol Chem.
Results represent the mean f SD (N = 5) Several experiments were performed to address the mechanism by which the ICAM- 1 antlsense ohgonucleotlde inhibited leukocyte migration. There was no slgmficant effect of the oligonucleotide on hematology parameters, including leukocyte number or differential leukocyte counts. Therefore, the decrease m leukocyte emlgratlon was not the result of the ohgonucleotide producing a neutropemc state. Cells that infiltrated the graft were predominately neutrophlls and monocytes (data not shown).
Thus, ~5% of the material sampled 5 min after injection could be detected by 100 mm. In contrast to the fmdmgs with phosphodiester material, gel electrophoretic analysis of CSF samples following phosphorothioate bolus injection revealed only intact ODN even after 50 Neckers et al. 100 mm. Again, these findings are consistent with the pattern of stability observed in vitro in the presence of fresh bram slices. Preliminary results have suggested that resistance to degradation does not require an all-phosphorothioate molecule.
Antisense Therapeutics by Sudhir Agrawal