New PDF release: Antiplatelet and Anticoagulation Therapy

By Stan Heptinstall B.Sc., Ph.D. (auth.), Albert Ferro, David A. Garcia (eds.)

ISBN-10: 1447142969

ISBN-13: 9781447142966

ISBN-10: 1447142977

ISBN-13: 9781447142973

This name can be offered as hugely functional info pn pharmaceutical antiplatelet and anticoagulation treatment, written in a quick-access, no-nonsense structure. The emphasis might be on a just-the-facts medical method, heavy on tabular fabric, gentle on dense prose. The involvement of the ISCP will make sure that the very best quality participants could be concerned and identify a constant method of every one subject within the sequence. each one quantity is designed to be among a hundred and twenty and 250 pages containing sensible illustrations and designed to enhance comprehend and functional utilization of cardiovascular medicines in particular scientific areas.

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Extra resources for Antiplatelet and Anticoagulation Therapy

Example text

Its use as an antithrombotic agent in stroke when used in combination with aspirin was established by the ESPS2 Study [71]. Another drug with a pharmacological profile similar to that of dipyridamole is cilostazol [72]. This also combines Chapter 1. 15 (a) Adenosine generated in the presence of dipyridamole counters the effect of ADP on cAMP; (b) a P2Y12 antagonist prevents ADP lowering cAMP allowing adenosine to provide very effective inhibition of platelet function 32 S. Heptinstall inhibition of a phosphodiesterase enzyme with the ability to inhibit adenosine uptake.

1983;15 Suppl 1:39S–44. 35. Lonsdale RJ, Heptinstall S, Westby JC, Berridge DC, Wenham PW, Hopkinson BR, Makin GS. A study of the use of the thromboxane A2 antagonist, sulotroban, in combination with streptokinase for local thrombolysis in patients with recent peripheral arterial occlusions: clinical effects, platelet function and fibrinolytic parameters. Thromb Haemost. 1993;69:103–11. 36. Pulcinelli FM, Pignatelli P, Pesciotti M, Sebastiani S, Parisi S, Gazzaniga PP. Mechanism of the persisting TxA2 receptor antagonism by picotamide.

Role of adenosine uptake and metabolism by blood cells in the antiplatelet actions of dipyridamole, dilazep and nitrobenzylthioinosine. Biochem Pharmacol. 1985;34:3965–72. Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A. European stroke prevention study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci. 1996;143:1–13. Chapter 1. Antiplatelet Agents: Current and Novel 43 72. Liu Y, Shakur Y, Yoshitake M, Kambayashi JiJ. Cilostazol (pletal): a dual inhibitor of cyclic nucleotide phosphodiesterase type 3 and adenosine uptake.

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Antiplatelet and Anticoagulation Therapy by Stan Heptinstall B.Sc., Ph.D. (auth.), Albert Ferro, David A. Garcia (eds.)


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